Background: Type 2 Diabetes Mellitus (T2DM) is a significant global health concern, often leading to microvascular complications such as Diabetic Nephropathy, a major cause of chronic kidney disease. The objective of this study was to assess the association between plasma Sialic Acid (SA) levels and C-Reactive Protein (CRP), along with other laboratory indicators of the Diabetic Nephropathy in Syrian patients. Materials and Methods: The study included 115 participants divided into 3 groups: 33 T2DM patients without complications, 52 with Diabetic Nephropathy, and 30 healthy controls. Parameters like plasma Glucose, Urea, Creatinine, C-Reactive Protein (CRP), and Urine Microalbumin were measured using available kits. SA levels were determined using Ehrlich’s method, and eGFR was calculated using the Cockcroft–Gault formula. Results: T2DM patients, especially those with Nephropathy, showed significant increasing in plasma Glucose, SA, CRP, Creatinine, Urea, and Urine Microalbumin compared to control. A positive correlation was observed between SA levels and these parameters, and a notable negative correlation with eGFR. Conclusion: Plasma SA levels are significantly elevated in Syrian T2DM patients with Nephropathy. These findings suggest that SA could be a potential biomarker for Diabetic Nephropathy in Syrian patients, offering a predictive tool for early diagnosis and preventive strategies for managing this complication