Compatibility and Chemical Stability Study of Bilayer Tablets Pharmaceutical Dosage Form of Aspirin/Clopidogrel as Eudragit L100 Polymer Main Excipient

الـجــامعــــة الــوطنيـــــة الـخــاصـــــة

الواحة الأكاديمية للجامعة الوطنية الخاصة

Abstract :

Due to the multiple diseases in the same patients, and the multiple medications they were taking, it was necessary to formulate medications containing two or more pharmaceutical substances to reduce the patient’s dosage and, as a result, reduce side effects. In this study aspirin and clopidogrel were formulated together in a pharmaceutical dosage form that ensures the chemical and physical stability. By wet granulation method as a first layer for clopidogrel as eduragit L100 as a polymer, which is considered an inner granule that achieves acceptable properties. The study formulates bilayer tablets containing aspirin and clopidogrel, using Eudragit L100-coated clopidogrel granules to minimize direct contact between the two drugs. Tablets were produced by wet granulation and evaluated for physical quality, dissolution, disintegration, and accelerated stability (40˚C/60% RH, three months) for the first study, and another condition (50˚C/75% RH, three months). Results show acceptable tablet hardness, friability, disintegration, and 94% – 99% drug content after accelerated testing, indicating chemical compatibility. The authors conclude that the bilayer design with Eudragit L100 improves stability of the aspirin-clopidogrel combination.

Participating researchers :

Fatima Khaled Al-Assaf – Student at the Faculty of Pharmacy- Al-Wataniya Private University

Fatima Mohammed Al-Nasser-Student at the Faculty of Pharmacy- Al-Wataniya Private University

Halima Mahmoud Al-Rahhal -Student at the Faculty of Pharmacy- Al-Wataniya Private University

Publisher :

(Open Access Library Journal) Scientific research publishing an academic publisher Q4

Research Link :

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Al-Wataniya Private University

It was established in 2007 and includes six colleges:

الـجــامعــــة الــوطنيـــــة الـخــاصـــــة

الواحة الأكاديمية للجامعة الوطنية الخاصة

Researcher: Dr. Mohammad A. Alassaf

Researcher: Dr. Mohammad F Manna

Al-Wataniya Private University

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