The pharmaceutical formulation stability of drug during its entire shelf life is an important matter and it is affected by many factors, one of the most important of these factors is the environmental conditions encountered during transport, storage and use. As know, the electricity access in developing countries might be a problem and the outage power may impact the stability of refrigerated pharmaceutical products.The aim of this study is to measured chemical and physical stability of dexamethasone sodium phosphate and chloramphenicol eye drops stored at room temperature while the recommended condition storage is between (2-8C°)