Preparation and Evaluation of Topical Formulations Containing Arctium lappa L. Root Extract for the Treatment of Acne

Abstract

This study aims to formulate and evaluate topical cream and toner containing Arctium lappa root extract as a promising natural alternative treatment for acne vulgaris. Acne is a common dermatological disorder associated with sebum overproduction, follicular hyperkeratinization, and cutibacterium acnes proliferation, leading to cutaneous inflammation.

The active compounds were extracted from burdock roots using 70% ethanolic extraction, and then incorporated into carefully designed cream and toner formulations. Both preparations underwent comprehensive physicochemical testing to evaluate parameters including pH, appearance, viscosity, stability, and spreadability.

Analysis results demonstrated that the cream exhibits skin-compatible pH (5.4) and a viscosity of 18,257 centipoise (cP), with no phase separation or particle aggregation observed following centrifugation, along with excellent spreadability characteristics.

The findings highlight the efficacy of burdock root extract (Arctium lappa) as a phytochemical component, with published studies confirming its significant antibacterial and anti-inflammatory properties. The study recommends conducting additional clinical trials to establish optimal dosage parameters and enhance the formulation's therapeutic efficacy.