DETERMINION of DICLOFENAC SODIUM IN TABLETS FORMULATIONS by DEREVATIVE SPECTROPHOTOMETRY
DOI:
https://doi.org/10.5281/zenodo.20230537Keywords:
Diclofenac Sodium, Spectrophotometric, Absorption, 1DS Derivative SpectrophotometryAbstract
A new sensitive, simple, rapid, precise, accurate, economical and reproducible derivative spectrophotometric method has been developed. It requires no prior separation for the estimation of Diclofenac Sodium (Dic.Na) in tablets pharmaceutical form. First order spectrophotometric derivative method was adopted to eliminatespectral interference. The first order derivative absorption wavelength of (Dic.Na) was found to be 255 nm, dissolved in NaOH medium (1M). This wavelength was selected for the analysis of (Dic.Na) at 255 nm, obeyed Beer-Lambert's law in the concentrationsrange of 0.5 -32 μg/mL. Regression analysis showed a good correlation coefficient R2 = 0.9999. The limit of detection (LOD) and limit of quantification (LOQ) were to be 0.05 and 0.15 μg/mL respectively .The proposed method has been successfully applied in analyzing (Dic.Na) in some Syrian trademark drugs. All studied samples showed that the drug level was in conformity with the United State Pharmacopeia (USP) legislation
Downloads
References
[1] K. Jana, L. Adhikari, S. K. Moitra, and A. A. Beher, “Analysis of multicomponent drug formulations: Diclofenac and paracetamol,” Asian J. Pharm. Clin. Res., vol. 4, no. 2, pp. 41–43, 2011.
[2] S. Naveed and F. Qamar, “UV spectrophotometric assay of diclofenac sodium available brands,” J. Innov. Pharm. Biol. Sci., vol. 1, no. 3, pp. 92–96, 2014.
[3] A. B. M. Mahood and M. J. Hamezh, “Spectrophotometric determination of diclofenac sodium in pharmaceutical preparations,” J. Kerbala Univ., vol. 7, no. 2, pp. 310–316, 2009.
[4] A. R. Khaskheli, M. Sirajuddin, K. Abro, S. T. H. Sherazi, H. I. Afridi, S. A. Mahesar, and M. Saeed, “Simpler and faster spectrophotometric determination of diclofenac sodium in tablets, serum and urine samples,” Pak. J. Anal. Environ. Chem., vol. 10, no. 1–2, pp. 53–58, 2009.
[5] G. Pandey, “Spectrophotometric methods for estimation of diclofenac sodium in tablets,” Int. J. Biomed. Adv. Res., vol. 4, no. 2, pp. 77–82, 2013.
[6] E. G. Ciapina, A. O. Santini, P. L. Weinert, M. A. Gotardo, H. R. Pezza, and L. Pezza, “Spectrophotometric determination of diclofenac sodium in pharmaceutical preparation assisted by microwave oven,” Quimica, vol. 30, no. 1, 2005.
[7] C. M. Monzón, M. D. C. Sarno, and M. R. Delfino, “Kinetic-spectrophotometric method for diclofenac quantification,” IOSR J. Pharm., vol. 2, no. 5, pp. 13–17, 2012.
[8] S. T. Ulu, “New and sensitive spectrofluorometric method for the determination of non-steroidal anti-inflammatory drugs, etodolac and diclofenac sodium in pharmaceutical preparations through derivatization with 7-fluoro-4-nitrobenzo-2-oxa-1,3-diazole,” J. Food Drug Anal., vol. 19, no. 1, 2011.
[9] M. A. Castillo and L. Bruzzone, “Indirect fluorometric determination of diclofenac sodium,” Anal. Sci., vol. 22, pp. 431–433, 2006.
[10] S. Jawla and S. Jain, “Atomic absorption spectrometric method for estimation of diclofenac sodium and mefenamic acid in pharmaceutical formulations,” Int. J. Pharm. Sci. Drug Res., vol. 2, no. 1, pp. 45–47, 2010.
[11] B. Yilmaz, S. Kaban, B. K. Akay, and U. Ciltas, “Differential pulse voltammetry determination of diclofenac sodium in pharmaceutical preparations and human serum,” Braz. J. Pharm. Sci., vol. 51, no. 2, 2015.
[12] B. Yilmaz and U. Ciltas, “Determination of diclofenac sodium in pharmaceutical preparations by voltammetry and gas chromatography methods,” J. Pharm. Anal., vol. 5, no. 3, pp. 153–160, 2015.
[13] M. Xu et al., “Polarographic behaviors of diclofenac sodium in the presence of dissolved oxygen and its analytical application,” Anal. Biochem., 2004.
[14] T. Iliescu, M. Baia, and V. Miclaus, “A Raman spectroscopic study of the diclofenac sodium–β-cyclodextrin interaction,” Eur. J. Pharm. Sci., vol. 22, no. 5, pp. 487–495, 2004.
[15] S. Mazurek and R. Szostak, “Quantitative determination of diclofenac sodium in solid dosage forms by FT-Raman spectroscopy,” J. Pharm. Biomed. Anal., vol. 48, no. 3, pp. 814–821, 2008.
[16] B. T. Alquadeib, “Development and validation of a new HPLC analytical method for determination of diclofenac sodium in tablets,” Saudi Pharm. J., vol. 27, no. 1, pp. 66–70, 2019.
[17] A. V. Gotoskar and V. J. Bhat, “Estimation of diclofenac sodium in SEDDS formulation by HPLC,” Int. J. Pharma Res. Rev., vol. 3, no. 4, pp. 1–11, 2014.
[18] R. A. Atto, “New method for determination of diclofenac sodium by HPLC,” Tikrit J. Pharm. Sci., vol. 8, no. 1, pp. 60–67, 2023.
[19] I. Nugrahani and N. Dillen, “Rapid assay development of diclofenac sodium coated tablet assay using FTIR compared to HPLC method,” Int. J. Pharm., vol. 10, no. 4, pp. 43–50, 2018.
[20] E. J. Pandya, P. Kapupara, and K. V. Shah, “Development and validation ofsimultaneous estimation of diclofenac potassium, paracetamol and serratiopeptidase by first order derivative UV spectroscopy method in pharmaceutical formulation,” J. Chem. Pharm. Res., vol. 6, no. 5, pp. 912–924, 2014.
[21] United States Pharmacopeial Convention, United States Pharmacopeia and National Formulary (USP 44–NF 39). Rockville, MD, USA, 2021.
[22] G. D. Christian, P. K. Dasgupta, and K. A. Schug, Analytical Chemistry. Hoboken, NJ, USA: Wiley, 2013.
Downloads
Published
Issue
Section
Categories
License
Copyright (c) 2024 Al-Wataniya Private University
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
